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Quetiapine lowered breeding and fertility in male Sprague-Dawley rats at dental dosages of 50 and also 150 mg/kg or around 1 and also 3 times the max human dose (MRHD) of 800 mg/day on mg/m2 body surface area. Drug-related results consisted of boosts in interval to mate as well as in the number of breedings needed for effective impregnation. These effects remained to be observed at 3 times the MRHD even after a two-week duration without treatment. The no-effect dose for impaired mating and also fertility in male rats was 25 mg/kg, or 0.3 times the MRHD dosage on mg/m2 physical body surface location. Quetiapine adversely had an effect on mating as well as fertility in women Sprague-Dawley rats at a dental dose roughly 1 times the MRHD of 800 mg/day on mg/m2 physical body surface location. Drug-related results included decreases in breedings and in matings leading to maternity, and also a rise in the interval to mate. A rise in uneven estrus patterns was noted at dosages of 10 as well as 50 mg/kg, or approximately 0.1 and also 1 times the MRHD of 800 mg/day on mg/m2 body area. The no-effect dosage in female rats was 1 mg/kg, or 0.01 times the MRHD of 800 mg/day on mg/m2 body area.

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